Publications

Last updated 26/08/2025

Almet AA, Yuan H, Annusver K, Ramos R, Liu Y, Wiedemann J, Sorkin DH, Landén NX, Sonkoly E, Haniffa M, Nie Q, Lichtenberger BM, Luecken MD, Andersen B, Tsoi LC, Watt FM, Gudjonsson JE, Plikus MV, Kasper M. A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization. J Invest Dermatol. 2023 Sep;143(9):1667-1677. doi: 10.1016/j.jid.2023.03.1679. PMID: 37612031; PMCID: PMC10610458.

Aouad P, Quinn HM, Berger A, Brisken C. Tumor dormancy: EMT beyond invasion and metastasis. Genesis. 2024 Feb;62(1):e23552. doi: 10.1002/dvg.23552. Epub 2023 Sep 30. PMID: 37776086.

Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nat Commun. 2022 Aug 25;13(1):4975. doi: 10.1038/s41467-022-32523-6. PMID: 36008376; PMCID: PMC9411634.

Bakiri L, Hasenfuss SC, Guío-Carrión A, Thomsen MK, Hasselblatt P, Wagner EF. Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2404188121. doi: 10.1073/pnas.2404188121. Epub 2024 Apr 24. PMID: 38657045; PMCID: PMC11067056.

Bakiri L, Schett G, Wagner F. Mechanism of chronic inflammation in psoriasis-like skin and joint disease. SPECTRUM Dermatologie. SD 04|2022, Nov 24.

Bakiri L, Wagner F. How does inflammation spread through the body? EU Research. Spring issue, vol. (34).

Bakiri L. Open Thy Lattice Osteoclast, Resorb me! J Cell Biol. 2023 Apr 3;222(4):e202302033. doi: 10.1083/jcb.202302033. Epub 2023 Mar 16. PMID: 36928467; PMCID: PMC10040631.

Bakiri, L., Tichet, M., Marques, C., Thomsen, M. K., Allen, E. A., Stolzlechner, S., Cheng, K., Matsuoka, K., Squatrito, M., Hanahan, D., & Wagner, E. F. (2025). A new effLuc/Kate dual reporter allele for tumor imaging in mice. Disease models & mechanisms, 18(1), DMM052130. https://doi.org/10.1242/dmm.052130.

Bakiri, L., Hasenfuss, S. C., Guío-Carrión, A., Thomsen, M. K., Hasselblatt, P., & Wagner, E. F. (2024). Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc. Proceedings of the National Academy of Sciences of the United States of America, 121(18), e2404188121. https://doi.org/10.1073/pnas.2404188121

Blair L, Pattison MJ, Chakravarty P, Papoutsopoulou S, Bakiri L, Wagner EF, Smale S, Ley SC. TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages. J Immunol. 2022 Feb 15;208(4):941-954. doi: 10.4049/jimmunol.2100213. Epub 2022 Jan 26. PMID: 35082159; PMCID: PMC9012084.

Bode, H. F., He, L., Hjelmborg, J. V. B., Kaprio, J., & Ollikainen, M. (2024). Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors. Clinical epigenetics, 16(1), 160. https://doi.org/10.1186/s13148-024-01767-y

Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M. Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer. Twin Res Hum Genet. 2022 Oct;25(4-5):171-179. doi: 10.1017/thg.2022.32. Epub 2022 Sep 8. PMID: 36073160.

Chiorino G, Petracci E, Sehovic E, Gregnanin I, Camussi E, Mello-Grand M, Ostano P, Riggi E, Vergini V, Russo A, Berrino E, Ortale A, Garena F, Venesio T, Gallo F, Favettini E, Frigerio A, Matullo G, Segnan N, Giordano L. Plasma microRNA ratios associated with breast cancer detection in a nested case-control study from a mammography screening cohort. Sci Rep. 2023 Jul 25;13(1):12040. doi: 10.1038/s41598-023-38886-0. PMID: 37491482; PMCID: PMC10368693.

Chrysanthou E, Sehovic E, Ostano P, Chiorino G. Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples. Cells. 2022 Mar 24;11(7):1099. doi: 10.3390/cells11071099. PMID: 35406661; PMCID: PMC8997401.

Constantin, C., Matvienko, D., László, C., Scabia, V., Battista, L., Binz, P. A., Bruce, S. J., & Brisken, C. (2025). Mimicking women’s endocrine milieu in mice for women’s health-related studies. npj women’s health, 3(1), 13. https://doi.org/10.1038/s44294-025-00060-4

Flaherty RL, Sflomos G, Brisken C. Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma? Endocrinology. 2024 Mar 29;165(5):bqae031. doi: 10.1210/endocr/bqae031. PMID: 38551031; PMCID: PMC10988861.

Gago-López N, Lagunas Arnal C, Perez JJ, Wagner EF. Topical application of an amygdalin analogue reduces inflammation and keratinocyte proliferation in a psoriasis mouse model. Exp Dermatol. 2021 Nov;30(11):1662-1674. doi: 10.1111/exd.14390. Epub 2021 May 28. PMID: 33998705; PMCID: PMC8597152.

Geukens, T., De Schepper, M., Van Den Bogaert, W., Van Baelen, K., Maetens, M., Pabba, A., Mahdami, A., Leduc, S., Isnaldi, E., Nguyen, H. L., Bachir, I., Hajipirloo, M., Zels, G., Van Cauwenberge, J., Borremans, K., Vandecaveye, V., Weynand, B., Vermeulen, P., Leucci, E., Baietti, M. F., … Desmedt, C. (2024). Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program. NPJ breast cancer, 10(1), 31. https://doi.org/10.1038/s41523-024-00637-3.

Ghosh S, Isma J, Ostano P, Mazzeo L, Toniolo A, Das M, White JR, Simon C, Paolo Dotto G. Nuclear lamin A/C phosphorylation by loss of androgen receptor leads to cancer-associated fibroblast activation. Nat Commun. 2024 Sep 12;15(1):7984. doi: 10.1038/s41467-024-52344-z. PMID: 39266569; PMCID: PMC11392952.

Huysentruyt, J., Steels, W., Ruiz Perez, M., Verstraeten, B., Vadi, M., Divert, T., Flies, K., Takahashi, N., Lambrecht, B. N., Declercq, W., Vanden Berghe, T., Maelfait, J., Vandenabeele, P., & Tougaard, P. (2024). RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis. Cell death and differentiation, 31(6), 820–832. https://doi.org/10.1038/s41418-024-01301-w

Matsuoka K, Bakiri L, Bilban M, Toegel S, Haschemi A, Yuan H, Kasper M, Windhager R, Wagner EF. Metabolic rewiring controlled by c-Fos governs cartilage integrity in osteoarthritis. Ann Rheum Dis. 2023 Sep;82(9):1227-1239. doi: 10.1136/ard-2023-224002. Epub 2023 Jun 21. PMID: 37344157; PMCID: PMC10423482.

Mazzeo L, Ghosh S, Di Cicco E, Isma J, Tavernari D, Samarkina A, Ostano P, Youssef MK, Simon C, Dotto GP. ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation. Nat Commun. 2024 Feb 3;15(1):1038. doi: 10.1038/s41467-024-45308-w. PMID: 38310103; PMCID: PMC10838290.

Mellor LF, Gago-Lopez N, Bakiri L, Schmidt FN, Busse B, Rauber S, Jimenez M, Megías D, Oterino-Soto S, Sanchez-Prieto R, Grivennikov S, Pu X, Oxford J, Ramming A, Schett G, Wagner EF. Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease. Ann Rheum Dis. 2022 Jul 4;81(10):1400–8. doi: 10.1136/annrheumdis-2022-222229. Epub ahead of print. PMID: 35788494; PMCID: PMC9484400.

Novoszel P, Drobits B, Holcmann M, Fernandes CS, Tschismarov R, Derdak S, Decker T, Wagner EF, Sibilia M. The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity. Cell Death Differ. 2021 Aug;28(8):2404-2420. doi: 10.1038/s41418-021-00765-4. Epub 2021 Mar 23. PMID: 33758366; PMCID: PMC8329169.

Novoszel P, Holcmann M, Stulnig G, De Sa Fernandes C, Zyulina V, Borek I, Linder M, Bogusch A, Drobits B, Bauer T, Tam-Amersdorfer C, Brunner PM, Stary G, Bakiri L, Wagner EF, Strobl H, Sibilia M. Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells. EMBO Mol Med. 2021 Apr 9;13(4):e12409. doi: 10.15252/emmm.202012409. Epub 2021 Mar 16. PMID: 33724710; PMCID: PMC8033525.

Palomo-Irigoyen, M., Bakiri, L., Hendrikx, T., Hayer, S., Schaffenrath, J., Widder, S., Bachg, S., Simmons, J., Gallo, R. L., Starkl, P., Roth, J., & Wagner, E. F. (2025). Chronic skin and systemic inflammation modulated by S100A8 and S100A9 complexes. Cell death and differentiation, 10.1038/s41418-025-01504-9. Advance online publication. https://doi.org/10.1038/s41418-025-01504-9

Petruzzelli M, Ferrer M, Schuijs MJ, Kleeman SO, Mourikis N, Hall Z, Perera D, Raghunathan S, Vacca M, Gaude E, Lukey MJ, Jodrell DI, Frezza C, Wagner EF, Venkitaraman AR, Halim TYF, Janowitz T. Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia. Cancers (Basel). 2022 Feb 15;14(4):963. doi: 10.3390/cancers14040963. PMID: 35205709; PMCID: PMC8870098.

Pires, M. J., Alam, S., Lovric, A., Fabbrizi, E., Rotili, D., Altun, M., & Valerie, N. C. K. (2025). Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells. The Journal of biological chemistry, 301(4), 108361. https://doi.org/10.1016/j.jbc.2025.108361

Pototschnig I, Feiler U, Diwoky C, Vesely PW, Rauchenwald T, Paar M, Bakiri L, Pajed L, Hofer P, Kashofer K, Sukhbaatar N, Schoiswohl G, Weichhart T, Hoefler G, Bock C, Pichler M, Wagner EF, Zechner R, Schweiger M. Interleukin-6 initiates muscle- and adipose tissue wasting in a novel C57BL/6 model of cancer-associated cachexia. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):93-107. doi: 10.1002/jcsm.13109. Epub 2022 Nov 9. PMID: 36351437; PMCID: PMC9891934.

Quinn, H. M., Battista, L., Scabia, V., & Brisken, C. (2024). Preclinical Mouse Intraductal Model (MIND) to Study Metastatic Dormancy in Estrogen Receptor-Positive Breast Cancer. Methods in molecular biology (Clifton, N.J.), 2811, 101–112. https://doi.org/10.1007/978-1-0716-3882-8_7

Ronchi C, Brisken C. Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form! Clin Cancer Res. 2023 Mar 1;29(5):833-834. doi: 10.1158/1078-0432.CCR-22-3374. PMID: 36547665.

Ronchi, C., Haider, S., & Brisken, C. (2024). EMBER creates a unified space for independent breast cancer transcriptomic datasets enabling precision oncology. NPJ breast cancer, 10(1), 56. https://doi.org/10.1038/s41523-024-00665-z

Ronchi, C., Ambrosini, G., Hughes, F., Flaherty, R. L., Quinn, H. M., Matvienko, D., Agnoletto, A., & Brisken, C. (2025). biogrowleR: Enhancing Longitudinal Data Analysis. Journal of mammary gland biology and neoplasia, 30(1), 9. https://doi.org/10.1007/s10911-025-09583-7

Samarkina A, Youssef MK, Ostano P, Ghosh S, Ma M, Tassone B, Proust T, Chiorino G, Levesque MP, Goruppi S, Dotto GP. Androgen receptor is a determinant of melanoma targeted drug resistance. Nat Commun. 2023 Oct 14;14(1):6498. doi: 10.1038/s41467-023-42239-w. PMID: 37838724; PMCID: PMC10576812.

Scabia V, Ayyanan A, De Martino F, Agnoletto A, Battista L, Laszlo C, Treboux A, Zaman K, Stravodimou A, Jallut D, Fiche M, Bucher P, Ambrosini G, Sflomos G, Brisken C. Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor. Nat Commun. 2022 Jun 6;13(1):3127. doi: 10.1038/s41467-022-30898-0. PMID: 35668111; PMCID: PMC9170711.

Scatolini M, Patel A, Grosso E, Mello-Grand M, Ostano P, Coppo R, Vitiello M, Venesio T, Zaccagna A, Pisacane A, Sarotto I, Taverna D, Poliseno L, Bergamaschi D, Chiorino G. GJB5 association with BRAF mutation and survival in cutaneous malignant melanoma. Br J Dermatol. 2022 Jan;186(1):117-128. doi: 10.1111/bjd.20629. Epub 2021 Oct 10. PMID: 34240406.

Schernhammer, E., Bogl, L., Hublin, C., Strohmaier, S., Zebrowska, M., Erber, A., Haghayegh, S., Papantoniou, K., Ollikainen, M., & Kaprio, J. (2023). The association between night shift work and breast cancer risk in the Finnish twins cohort. European journal of epidemiology, 38(5), 533–543. https://doi.org/10.1007/s10654-023-00983-9

Sehovic E, Urru S, Chiorino G, Doebler P. Meta-analysis of diagnostic cell-free circulating microRNAs for breast cancer detection. BMC Cancer. 2022 Jun 9;22(1):634. doi: 10.1186/s12885-022-09698-8. PMID: 35681127; PMCID: PMC9178880.

Sehovic E, Zellers SM, Youssef MK, Heikkinen A, Kaprio J, Ollikainen M. DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study. Clin Epigenetics. 2023 Nov 10;15(1):181. doi: 10.1186/s13148-023-01594-7. PMID: 37950287; PMCID: PMC10638786.

Sehovic, E., Gregnanin, I., Mello-Grand, M., Ostano, P., Vergini, V., Ortale, A., Amoruso, A., Favettini, E., Segnan, N., Chiorino, G., Giordano, L., & Petracci, E. (2024). Confirmation of previously identified plasma microRNA ratios for breast cancer detection in a nested case-control study within a screening setting. Clinical and translational medicine, 14(11), e70068. https://doi.org/10.1002/ctm2.70068

Sflomos G, Schaumann N, Christgen M, Christgen H, Bartels S, Kreipe H, Battista L, Brisken C. Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma. Cancers (Basel). 2023 Jun 22;15(13):3299. doi: 10.3390/cancers15133299. PMID: 37444409; PMCID: PMC10340059.

Talwelkar SS, Mäyränpää MI, Søraas L, Potdar S, Bao J, Hemmes A, Linnavirta N, Lømo J, Räsänen J, Knuuttila A, Wennerberg K, Verschuren EW. Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments. Cell Rep Med. 2021 Aug 17;2(8):100373. doi: 10.1016/j.xcrm.2021.100373. PMID: 34467250; PMCID: PMC8385325.

Urwyler-Rösselet C, Tanghe G, Devos M, Hulpiau P, Saeys Y, Declercq W. Functions of the RIP kinase family members in the skin. Cell Mol Life Sci. 2023 Sep 9;80(10):285. doi: 10.1007/s00018-023-04917-2. PMID: 37688617; PMCID: PMC10492769.

Valerie, N. C. K., Sanjiv, K., Mortusewicz, O., Zhang, S. M., Alam, S., Pires, M. J., Stigsdotter, H., Rasti, A., Langelier, M. F., Rehling, D., Throup, A., Purewal-Sidhu, O., Desroses, M., Onireti, J., Wakchaure, P., Almlöf, I., Boström, J., Bevc, L., Benzi, G., Stenmark, P., … Altun, M. (2024). Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM. Nature communications, 15(1), 10347. https://doi.org/10.1038/s41467-024-54415-7

Xie H, Heier C, Meng X, Bakiri L, Pototschnig I, Tang Z, Schauer S, Baumgartner VJ, Grabner GF, Schabbauer G, Wolinski H, Robertson GR, Hoefler G, Zeng W, Wagner EF, Schweiger M, Zechner R. An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112840119. doi: 10.1073/pnas.2112840119. PMID: 35210363; PMCID: PMC8892347.